Startups

TechCrunch+ roundup: New VC rules, AI biotech investor survey, Instagram ad case study

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Houses in the Sea Cliff neighborhood of San Francisco, California, US, on Thursday, Dec. 15, 2022. California home sales plunged this year as soaring interest rates held back buyers in the costly state. Photographer: David Paul Morris/Bloomberg via Getty Images
Image Credits: Bloomberg (opens in a new window) / Getty Images

When a cat is scared, it may hide under the couch; a startled fish will swim into a dark hole. And when humans feel uneasy, we tell ourselves stories.

An example: “growth at all costs” is a fairy tale made possible by cheap money that helped venture capitalists set expectations for founders — and each other — for years.

Similarly, “everyone needs 18-24 months of runway” is a nice motto, but when it takes three times longer to raise a round than it used to, it may no longer be useful advice.

“These ‘VCisms’ borne out of an era of plenty have permeated boardrooms and investor meetings everywhere,” notes Neotribes Ventures partner Rebecca Mitchem in a TechCrunch+ post this morning.


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It’s time to ask ourselves if these VCisms are still relevant or if it’s time to change.

In a data-driven piece that looks at post-money valuations, deal sizes and dilution rates going back to 2012, Mitchem says we’re now heading into a new era where the tech industry will embrace “growth at reasonable costs.”

Founders can continue to water down their ownership by pursuing fat rounds, or they can decide to grow more slowly, which will leave everyone involved with a larger stake over time.

“While it may feel counterintuitive, given the recent market environment, the value of the equity for all parties — investors, founders and employees — is higher in the more conservative growth scenario,” says Mitchem.

Thanks very much for reading TC+ this week,

Walter Thompson
Editorial Manager, TechCrunch+
@yourprotagonist

The rules of VC are changing: Here’s what founders should be considering in the new era

6 investors discuss why AI is more than just a buzzword in biotech

Digital image of artificial intelligence human brain on black background.
Image Credits: Andriy Onufriyenko (opens in a new window) / Getty Images

Biotech firms widely use AI and machine learning to reduce R&D spending and bring products to market faster, but “the bigger question for investors is getting a better understanding of what exactly AI is attempting to model and predict,” says Shaq Vayda, principal at Lux Capital.

In her latest investor survey, Anna Heim spoke to six biotech investors about where AI creates value, short-term market shifts, and how they’d like to be approached by founders:

  • Robert Mittendorff, M.D, general partner and head of healthcare, B Capital
  • James Coates, health and human performance principal, Decisive Point
  • Shaq Vayda, principal, Lux Capital
  • Franck Lescure, partner, Elaia Partners
  • Francisco Dopazo, general partner, Humboldt Fund
  • Sarah Guo, founder, Conviction

6 investors discuss why AI is more than just a buzzword in biotech

Which Instagram ad placement is more cost-effective: Reels, Feed Posts or Stories?

Row of ice creams with different amounts of scoops
Image Credits: Jonathan Knowles (opens in a new window) / Getty Images

Consumer-facing startups are spending more on platforms like TikTok and Instagram to reach customers, but which ad products offer the best return?

In a case study based on Instagram campaigns for a site that facilitates bookings for freelance beauty professionals, digital marketer Angelina Liparteliani looked at Instagram Reels, Feed Posts and Stories.

Her highly detailed breakdown includes examples of the ads used in various campaigns, the process she used for optimizing creative materials and a cost-per-click analysis that shows how she reduced CPC from $1.51 to 17 cents.

“Definitely don’t chase trends,” advises Liparteliani. “Diversify your ad strategy, test different ideas and don’t give up if your ad doesn’t show results right away.”

Which Instagram ad placement is more cost-effective: Reels, Feed Posts or Stories?

Pitch Deck Teardown: MedCrypt’s $25M Series B deck

Image Credits: Medcrypt (opens in a new window)

Many medical devices are just as vulnerable to cybersecurity threats as other IoT products, which is why Y Combinator graduate MedCrypt creates software to protect patients.

The company predicts that manufacturers will need to secure $1 trillion of “new and legacy” devices over the next three years, a truly tantalizing TAM.

After redacting some customer adoption details, MedCrypt’s founders shared with TC+ the 12-slide deck that helped it raise a $25 million Series B:

  • Cover slide
  • Problem slide
  • Target audience/market size slide
  • Opportunity slide
  • Mission slide
  • Product slide: Vulnerability tracking
  • Product slide: Behavior monitoring
  • Product slide: Cryptography
  • Product slide: MedISAO
  • Team slide
  • Summary/traction slide

Pitch Deck Teardown: MedCrypt’s $25M Series B deck

Dear Sophie: When can I register my employee for the H-1B lottery?

lone figure at entrance to maze hedge that has an American flag at the center
Image Credits: Bryce Durbin/TechCrunch

Dear Sophie,

We’re a pre-seed startup thinking about sponsoring an early employee’s H-1B visa to stay in the U.S. and work for us.

How does the process work?

— Seeking in San Mateo

Dear Sophie: When can I register my employee for the H-1B lottery?

A guide to navigating your first 90 days as a new CISO

Red Colored Navigational Compass on Red Background Directly Above View.
Image Credits: MirageC (opens in a new window) / Getty Images

I’m used to working under pressure, but taking a job as a chief information security officer sounds extraordinarily stressful: People are far more likely to learn about your failures than your successes.

Managing the cybersecurity needs of an entire organization is “a big job that touches just about every part of the organization,” says Heather Gantt-Evans, CISO at SailPoint.

She’s written a guide for incoming CISOs that contains a framework for setting goals, creating action plans and, most importantly, documenting risk.

“The first 90 days of a new CISO’s term are critical,” writes Gantt-Evans. “They’re the best chance you’ll ever have to research, gather documentation and assess where things stand and how they can be improved.”

A guide to navigating your first 90 days as a new CISO

In a turbulent market, it’s time to get methodical about sales

Teacher preparing pencils for school day; aligning product team with product vision
Image Credits: Peter Dazeley (opens in a new window) / Getty Images

Many SaaS sales teams haven’t worked in an environment where so many customers are cutting back on spending, and it shows: When everyone’s in the mood to buy, it’s less important to develop a critical understanding of your customer’s needs.

“Sellers shouldn’t hop right into pushing features,” advises Steve Goldberg, chief revenue officer at Salesloft. “They should illustrate the unsustainable nature of a customer’s current behaviors and processes.”

In this post, Goldberg looks at MEDDPICC and design thinking, two sales methodologies that are “particularly effective when times get tough.”

In a turbulent market, it’s time to get methodical about sales

More TechCrunch

Apple is bringing ChatGPT, its AI-powered chatbot experience, to Siri and other Apple apps, powered by OpenAI’s GPT-4 and other generative AI models. Apple announced the news at its annual…

Apple brings ChatGPT to its apps, including Siri

An “Apple Intelligence” (aka AI)-powered feature coming in iOS 18 will allow iPhone users to create AI images of people they’re messaging with — a feature that works something like…

Apple debuts AI-generated … Bitmoji

To use InSight, Apple TV+ subscribers can swipe down on their remote to bring up a display with actor names and character information in real time.

Apple TV+ introduces InSight, a new feature similar to Amazon’s X-Ray, at WWDC 2024

Siri is now more natural, more relevant and more personal — and it has new look.

Apple gives Siri a makeover

The TechCrunch the team runs down all of the biggest news from the Apple WWDC 2024 keynote in an easy-to-skim digest.

Here’s everything Apple announced at the WWDC 2024 keynote, including Apple Intelligence, Siri makeover

Apple Tuesday unveiled Apple Intelligence, its long awaited, ecosystem-wide push into generative AI. As earlier rumors suggested, the new feature is called Apple Intelligent (A.I., get it?). The company promised…

Apple Intelligence is the company’s new generative AI offering

In addition to all the features you can find in the Passwords menu today, there’s a new column on the left that lets you more easily navigate your password collection.

Apple is launching its own password manager app

Apple announced at WWDC on Monday that iPadOS 18 will include a new “Smart Script” feature that will clean up your handwriting when using an Apple Pencil to write in…

Smart Script in iPadOS 18 will clean up your handwriting when using an Apple Pencil

iOS’ perennial tips calculating app is finally coming to the larger screen.

Calculator for iPad does the math for you

The new OS, announced at WWDC 2024, will allow users to mirror their iPhone screen directly on their Mac and even control it.

With macOS Sequoia, you can mirror your iPhone on your Mac

At Apple’s WWDC 2024, the company announced MacOS Sequoia.

Apple unveils MacOS Sequoia

“Messages via Satellite,” announced at Apple’s WWDC 2024 keynote, works much like the SOS feature did.

iPhones will soon text via satellite

Apple says the new design will lead to less time searching for photos.

Apple revamps its Photos app for iOS 18

Users will be able to lock an app when they hand over their phone.

iOS 18 will let you hide and lock apps

Today’s WWDC 2024 keynote has been packed so for, including a number of key new updates for iOS 18. One of the more interesting additions is Tap to Pay, which…

Tap to Cash lets you pay by touching iPhones

In iOS 18, Apple will now support long-requested functionality, like the ability to set app icons and widgets wherever you want.

iOS 18 will finally let you customize your icons and unlock them from the grid

Apple is sharing the first details for the upcoming major release of iOS, its operating system specifically designed for the iPhone. The company is holding its Worldwide Developers Conference (WWDC)…

Apple unveils iOS 18 with a myriad of AI-powered features

Apple today kicked off what it promised would be a packed WWDC 2024 with a handful of VisionOS announcements. At the top of the list, is the ability to turn…

VisionOS can now make spatial photos out of 3D images

The Apple Vision Pro is now available in eight new countries.

Apple to release Vision Pro in international markets

VisionOS 2 will come to Vision Pro as a free update later this year.

Apple debuts VisionOS 2 at WWDC 2024

The security firm said the attacks targeting Snowflake customers is “ongoing,” suggesting the number of affected companies may rise.

Mandiant says hackers stole a ‘significant volume of data’ from Snowflake customers

French startup Kelvin, which uses computer vision and machine learning to make it easier to audit homes for energy efficiency, has raised $5.1M.

Kelvin wants to help save the planet by applying AI to home energy audits

A last call and a major shoutout to any and all early-stage founders. It’s time to dig deep and take advantage of an unparalleled opportunity at TechCrunch Disrupt 2024 —…

Only hours left to apply to Startup Battlefield 200 at Disrupt

Privacy watchdogs in the U.K. and Canada have launched a joint investigation into the data breach at 23andMe last year.  On Monday, the U.K,’s Information Commissioner’s Office (ICO) and the…

UK and Canada privacy watchdogs investigating 23andMe data breach

Dubai-based fractional property investment platform Stake has raised $14 million in Series A funding.

Stake raises $14M to bring its fractional property investment platform to Saudi Arabia, Abu Dhabi

“We were motivated to fundraise because we think the ’24 vintage is going to be a good one,” founder Craig Shapiro said.

After hits like Reddit and Scopely, Collaborative Fund easily raised a $125M fund to tackle climate, health and food

The merger has yet to close due to extended due diligence amid ongoing restructuring and macroeconomic headwinds across multiple countries.

Sources: Wasoko-MaxAB e-commerce merger faces delays amid headwinds in Africa

The keynote will be focused on Apple’s software offerings and the developers that power them, including the latest versions of iOS, iPadOS, macOS, tvOS, visionOS and watchOS.

Watch Apple kick off WWDC 2024 right here

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